The Broad Institute (or, more formally, Eli and Edythe L. Broad Institute of MIT and Harvard) is a medical research group that works with MIT, Harvard University, and the five Harvard teaching hospitals to advance our knowledge of human health and medicine. A 501(c)(3) nonprofit, the organization was established in 2004 to create a group capable of cross-departmental research collaboration.

The Broad Institute has 11 major research programs: cancer, medical and population genetics, genome biology and cell circuits, chemical biology, metabolism, infectious disease, psychiatric research, genome sequencing and analysis, epigenomics, and vertebrate genomics. The Broad Institute was also crucial during the COVID-19 pandemic; it processed a large percentage of COVID tests submitted by doctors.